Factores asociados a la mortalidad en pacienteshospitalizados por COVID-19 en España. Datos del Registro Español de Resultadosde Farmacoterapia frente a COVID-19 (RERFAR) / Factors associated with mortality in patients hospitalized for COVID-19 in Spain. Data from the RERFAR registry
Farm. hosp
; 46(2): 1-15, Mar-Abr 2022. tab
Article
in Es
| IBECS
| ID: ibc-203857
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
RESUMEN
Objetivo:
Determinar las características basales que se asocian a unamayor mortalidad a los 42 días en aquellos pacientes hospitalizados porCOVID-19 en España.Método:
Cohorte prospectiva de pacientes COVID-19 hospitalizados.La variable dependiente fue la mortalidad a los 42 días. Además, serecogieron características demográficas, clínicas, comorbilidades, tratamientohabitual, intervenciones de soporte y tratamientos en las primeras48 horas del ingreso. Para determinar la asociación con la mortalidad, serealizó un análisis multivariante mediante regresión logística.Resultados:
Se incluyeron 15.628 pacientes, de ellos falleció el 18,2%(n = 2.806). El análisis multivariante mostró que las variables asociadassignificativamente (p < 0,05) con la mortalidad al ingreso fueron procederde un centro sociosanitario (odds ratio OR 1,9), frecuencia respiratoria (oddsratio 1,5), gravedad de neumonía (CURB-65) moderada (odds ratio 1,7) oalta (odds ratio 2,9), transaminasa aspartato aminotransferasa ≥ 100 UI/l(odds ratio 2,1), lactato-deshidrogenasa ≥ 360 UI/l (odds ratio 1,6), procalcitonina > 0,5 ng/ml (odds ratio 1,8), creatina-quinasa ≥ 294 U/l (odds ratio1,5), dímero D > 3.000 ng/ml (odds ratio 1,5), hemoglobina < 11,6 g/dl(odds ratio 1,4) y proteína C reactiva > 120 mg/l (odds ratio 1,2), necesidadde soporte respiratorio en las primeras 48 horas (odds ratio 2,0 deoxigenoterapia; odds ratio 2,8 ventilación no invasiva y odds ratio 3,5 ventilaciónmecánica) y tratamiento con interferón-beta (odds ratio 1,5). Por elcontrario, ser menor de 80 años se asoció a una menor mortalidad.Conclusiones:
El análisis del Registro Español de Resultados de Farmacoterapiafrente a COVID-19 muestra que los factores asociados a peorpronóstico son mayor edad, valoración mediante la escala CURB‑65, elnivel de requerimiento de soporte respiratorio, neumonía grave (CURB‑65),hipertransaminasemia, elevación de creatina-quinasa, lactato-deshidrogenasa,ABSTRACT
Objective:
To determine the baseline characteristics associated withhigher mortality at 42 days in patients hospitalized for COVID-19 inSpain.Method:
The study analyzed a prospective cohort of hospitalizedCOVID-19 patients. The dependent variable was 42-day mortality. Dataon the subjects demographic and clinical characteristics, comorbidities,usual therapy and supportive interventions and treatments was collectedwithin 48 hours from admission. To determine the potential associationof the data with mortality, a multivariate analysis was performed usinglogistic regression.Results:
15,628 patients were included, 18.2% of whom (n = 2,806)died during the study period. According to the multivariate analysis, thevariables that were significantly associated (p < 0.05) with mortality uponadmission were being referred from a nursing home (OR 1.9); havinga high respiratory rate (OR 1,5); having moderate (OR 1.7) or severe(OR 2.9) pneumonia (CURB-65); aspartate aminotransferase transaminase ≥ 100 IU/l (OR 2.1); lactate dehydrogenase ≥ 360 IU/L (OR 1.6);procalcitonin > 0.5 ng/mL (OR 1.8); creatine kinase ≥ 294 U/L (OR 1.5);D-dimer > 3,000 ng/mL (OR 1.5); hemoglobin< 11.6 g/dL (OR 1.4) andC-reactive protein > 120 mg/L (OR 1.2; requiring respiratory support withinthe first 48 hours (oxygen therapy [OR 2.0], non-invasive ventilation [OR 2.8],and mechanical ventilation [OR 3.5]); and being treated with interferon-beta(OR 1.5). On the contrary, being under 80 years of age was associated withlower mortality.Conclusions:
The analysis, based on the data in the RERFAR registry, showedthat the factors associated with poorer prognosis were older age, assessedusing the CURB-65 scale, level of respiratory support required, severe pneumonia(CURB-65), hypertransaminasemia, elevated creatine kinase, lactatedehydrogenase, and D-dimer levels, anemia, and elevated respiratory rate.Key words
Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Spain
/
Records
/
Hospital Mortality
/
Drug Therapy
/
Pandemics
/
Betacoronavirus
Limits:
Humans
Country/Region as subject:
Europa
Language:
Es
Journal:
Farm. hosp
Year:
2022
Document type:
Article